Meet the Brooks Men's Glycerin 22 Road Running Shoes — a pinnacle of plush, cloud-soft cushioning built for road miles and long runs. The secret is DNA Tuned, Brooks’ nitrogen-infused midsole that blends ultra-soft landings with responsive toe-offs so you feel propelled forward with every stride. In the heel, large cells cushion landings to keep your stride soft and steady; in the forefoot, smaller cells drive quick, energizing toe-offs that help you maintain pace without extra effort. This combination creates a ride that feels like you could run forever, even on your toughest road workouts.

Engineered for comfort without compromise, the Glycerin 22 uses a breathable, flexible double jacquard knit upper. This precise weave wraps your foot with a plush, accommodating hug that adapts as your pace changes—great for long runs when you need a shoe that moves with you rather than constrains you. The upper’s design also speaks to sustainability, with 61.3% of its materials sourced from recycled content, helping you feel good about every mile you log on the road.

Road-ready bones with a thoughtful footprint:

• Road-specific performance — optimized for long pavement miles with a nadir that keeps you stable and secure on uneven road surfaces.
• 10 mm midsole drop — a balanced geometry that supports a smooth heel-to-toe transition without sacrificing energy return.
• Weight 10.2 oz (289.2 g) — a manageable heft that delivers substantial cushioning while maintaining speed and agility.
• DNA Tuned cushioning — nitrogen-infused foam delivers generous landings with a responsive toe-off for effortless pacing.
• Broad platform — a stable base that helps you maintain form through fatigue, making it a strong choice for daily training and long runs alike.

Who should consider the Glycerin 22? Serious road runners chasing a cloud-soft ride that still propels their pace, athletes mounting back-to-back training days, and anyone who wants to protect joints on high-mileage weeks. It shines on long, steady runs, tempo efforts, and recovery days when cushioning is non-negotiable but you still need dependable turnover.

Compared to other road shoes, the Glycerin 22 leans into plush comfort with propulsion, rather than focusing solely on bounce or speed. Its thoughtful combination of a cushioned midsole, energy-forward toe-off, and a breathable, eco-conscious upper creates a balanced, durable companion for a wide range of workouts—without sacrificing ride quality as the miles stack up.

Pro tips for getting the most from your Glycerin 22: break them in gradually on easy routes to let the knit contour to your foot; pair with moisture-wicking socks to maximize comfort during longer sessions; and rotate with a lighter trainer on days focused on speed to preserve the soft feel when you need it most.

If you crave a cloud-soft ride that still drives you forward and preserves your stride efficiency, the Brooks Glycerin 22 is built to keep pace with your road-running goals.